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MilliporeSigma™ NB-2/Cntn5, Rat, Unlabeled, Clone: 1A6,

Catalog No. MABN877MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABN877MI 100 μg Unconjugated
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Catalog No. MABN877MI Supplier MilliporeSigma™ Supplier No. MABN877

Description

Rat Monoclonal Antibody

Contactin-5 (UniProt P68500; also known as Neural recognition molecule NB-2) is encoded by the Cntn5 gene (Gene ID 244682) in murine species. Contactin-5 (NB-2) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein belonging to a subgroup of the immunoglobulin superfamily of proteins known as contactins. Five of the six contactins, Contactin-1, contactin-2/TAG-1, contactin-3/BIG-1, contactin-4/BIG-2, and contactin-5/NB-2 are expressed by DRG neurons. Of these, contactin-1, TAG-1, and BIG-2, are also expressed by motor neurons. NB-2 plays an important role in synapse formation in the developing auditory system in rodents. Expression of NB-2 is seen in the central auditory pathways just before the onset of hearing in rodents and is localized at glutamatergic synapses in the postnatal auditory brainstem. NB-2-knockout mice exhibit abnormal responses to auditory stimuli in both neuronal excitability and behavior, and have delayed auditory brainstem response waves. In addition, NB-2 deficiency in mice causes a significant reduction in the number of synapses and induces apoptosis in a subset of neurons in the auditory brainstem. NB-2 is produced with an N-terminal signal peptide (a.a. 1-23) and a C-terminal propeptide (a.a. 1072-1098) sequence, the removal of which yields the mature GPI-anchored glycoprotein (a.a. 24-1071) with six C2-type Ig-like domains (a.a. 98-659) and four type-III fibronectin domains (a.a. 672-1066).
TRUSTED_SUSTAINABILITY

Specifications

Antigen NB-2/Cntn5
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 1A6
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Cntn5
Gene Accession No. P68500
Host Species Rat
Immunogen Human IgG Fc-tagged recombinant mouse NB-2/Cntn5.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_001164258
Test Specificity Clone 1A6 detected NB-2 in the synaptosomal, but not mitochondrial, fraction from mouse cerebral cortex homogenate (Shimoda, Y., et al. (2012). Neurosci. Lett. 510(2):148-153).
Target Species Mouse
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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For Research Use Only. Not for use in diagnostic procedures.

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