Invitrogen™ NCAPD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557886

Catalog No. PIPA557886

Description

Immunogen sequence: DKSVLVCKNA IQLLASFLAN NPFSCKLSDA DLAGPLQKET QKLQEMRAQR RTAAASAVLD PEEEWEAMLP ELKSTLQQLL QLPQGEEEIP EQIA Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt].

Specifications

• Antigen: NCAPD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NCAPD2
• Gene Alias: 2810406C15Rik; 2810465G24Rik; Capd2; CAP-D2; chromosome condensation related SMC associated protein 1; chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; CNAP1; Condensin complex subunit 1; hCAP-D2; KIAA0159; mCAP-D2; mKIAA0159; Ncapd2; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2; RGD1562596; XCAP-D2 homolog
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9918
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q15021
• Gene Symbols: NCAPD2
• Immunogen: Recombinant protein corresponding to Human NCAPD2. Recombinant protein control fragment (Product #RP-97627).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov