Invitrogen™ NCAPD2 Recombinant Rabbit Monoclonal Antibody (JE62-22)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544820

Catalog No. PIMA544820

Description

NCAPD2 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt].

Specifications

• Antigen: NCAPD2
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q15021
• Gene Symbols: NCAPD2
• Immunogen: Recombinant protein within human NCAPD2 aa 51-200/1,401.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: JE62-22
• Conjugate: Unconjugated
• Gene: NCAPD2
• Gene Alias: 2810406C15Rik; 2810465G24Rik; Capd2; CAP-D2; chromosome condensation related SMC associated protein 1; chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; CNAP1; Condensin complex subunit 1; hCAP-D2; KIAA0159; mCAP-D2; mKIAA0159; Ncapd2; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2; RGD1562596; XCAP-D2 homolog
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 9918
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid