Invitrogen™ NCAPH2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566964

Catalog No. PIPA566964

Description

Immunogen sequence: AAKLQDFHQWY LAAYADHADS RRLRRKGPSF ADMEVLYWTH VKEQLETLRK LQRREVAEQW LRPAEEDHLE DSLEDLGAAD DFLEPEEYME PEG Highest antigen sequence identity to the following orthologs - mouse 70%, rat 69%.

Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.

Specifications

• Antigen: NCAPH2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NCAPH2
• Gene Alias: CAPH2; CAP-H2 subunit of the condensin II complex; Chromosome-associated protein H2; condensin-2 complex subunit H2; CTA-384D8.36; D15Ertd785e; hCAP-H2; kleisin beta; Kleisin-beta; Ncaph2; Non-SMC condensin II complex subunit H2; non-SMC condensin II complex, subunit H2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29781
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6IBW4
• Gene Symbols: NCAPH2
• Immunogen: Recombinant Human NCAPH2. Recombinant protein control fragment (Product #RP-105440).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG