NCBP1/CBP80 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Bethyl Laboratories, Inc A301794A
The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with ChickenNCBP1, also known as CBP80, is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5 ft. cap of nascent pre-mRNA in the nucleoplasm. NCBP1 promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3 ft.-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Recent evidence has shown that cellular-cap-binding proteins such as NCBP1 associate with influenza virus mRNAs, suggesting that these viral mRNAs may follow the normal cellular pathways for splicing, nuclear export, and translation.
|Between 482 and 532|
|Antigen affinity chromatography|
|Immunohistochemistry, Immunoprecipitation, Western Blot|
|phosphate, tris citrate with 0.09% sodium azide; pH 7-8|
|RP11-546O6.1, CBP80, MGC2087, NCBP, Sto1, 80 kDa nuclear cap-binding protein; NCBP 80 kDa subunit; nuclear cap-binding protein subunit 1|
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