Invitrogen™ NCF2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551702

Catalog No. PIPA551702

Description

Immunogen sequence: QEESSPQSDI PAPPSSKAPG RPQLSPGQKQ KEEPKEVKLS VPMPYTLKVH YKYTVVMKTQ PGLPYSQVRD MVSKKLELRL EHTKLSYRPR DSNELVPLSE DSMKDAWGQV KNYCLTLWCE NTVGDQGFPD EPKESEKADA NNQTTEPQ Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 24%.

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.

Specifications

• Antigen: NCF2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NCF2
• Gene Alias: 67 kDa neutrophil oxidase factor; chronic granulomatous disease, autosomal 2; EMBL:FAA00361.1}; FLJ93058; NADPH oxidase activator 2; NADPH oxidase subunit (67 kD); NADPH oxidase subunit (67kDa); NCF2; NCF-2; ncf2 {ECO:0000312; neutrophil cytosol factor 2; neutrophil cytosolic factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); neutrophil NADPH oxidase factor 2; Noxa2; p67phox; p67-phox
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4688
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P19878
• Gene Symbols: NCF2
• Immunogen: Recombinant protein corresponding to Human NCF2. Recombinant protein control fragment (Product #RP-95408).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG