NCOA4 Monoclonal Antibody (OTI2F1), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA806569

Catalog No. 50-168-1167

Description

Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo. ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion. ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b is solely expressed in the testis. ARA70a can function as a ligand-enhanced co-activator of PPARg in adipocytes. ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.

Specifications

• Antigen: NCOA4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q13772
• Gene Symbols: NCOA4
• Immunogen: Human recombit protein fragment corresponding to amino acids 280-553 of human NCOA4 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2F1
• Conjugate: Unconjugated
• Gene: NCOA4
• Gene Alias: ARA70, ELE1, PTC3, RFG
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8031
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid