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NCOA4 Mouse anti-Human, Clone: OTI2G4, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF806402

Encompass_Preferred

Catalog No. 50-166-7826


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo. ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion. ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b is solely expressed in the testis. ARA70a can function as a ligand-enhanced co-activator of PPARg in adipocytes. ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.
Specifications

Specifications

NCOA4
Monoclonal
Unconjugated
NCOA4
ARA70, ELE1, PTC3, RFG
Mouse
Affinity Chromatography
RUO
8031
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI2G4
PBS with 8% trehalose and no preservative; pH 7.3
Q13772
NCOA4
Human recombit protein fragment corresponding to amino acids 280-553 of human NCOA4 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG1
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