NCOA4 Mouse anti-Human, Clone: OTI2G4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF806402

Catalog No. 50-166-7826

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo. ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion. ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b is solely expressed in the testis. ARA70a can function as a ligand-enhanced co-activator of PPARg in adipocytes. ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.

Specifications

• Antigen: NCOA4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: NCOA4
• Gene Alias: ARA70, ELE1, PTC3, RFG
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8031
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI2G4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q13772
• Gene Symbols: NCOA4
• Immunogen: Human recombit protein fragment corresponding to amino acids 280-553 of human NCOA4 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1