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Invitrogen™ NCOA4 Polyclonal Antibody
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Catalog No. PIPA564203
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PIPA564203 100 μL
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Catalog No. PIPA564203 Supplier Invitrogen™ Supplier No. PA564203
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KSPMNTSWCS FNTADWVLPG KKMGNLSQLS SGEDKWLLRK KAQEVLLNSP LQEEHNFPPD HYGLPAVCDL FACMQLKVDK EKWLYRTPLQ Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.

Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo. ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion. ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b is solely expressed in the testis. ARA70a can function as a ligand-enhanced co-activator of PPARg in adipocytes. ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NCOA4
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NCOA4
Gene Accession No. Q13772
Gene Alias 70 kDa androgen receptor coactivator; 70 kDa AR-activator; Androgen receptor coactivator 70 kDa protein; Androgen receptor-associated protein of 70 kDa; ARA70; ELE1; NCOA4; NCoA-4; Nuclear receptor coactivator 4; PTC3; ret fused; RET-activating gene ELE1; Ret-activating protein ELE1; RFG
Gene Symbols NCOA4
Host Species Rabbit
Immunogen Recombinant protein fragment of Human NCOA4 (Product #RP-103588)
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8031
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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