NCR2 Mouse anti-Human, Clone: OTI4B8, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF809536

Catalog No. 50-166-9567

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

CD336 is also known as NKp44 or NCR2. CD336 is a 44-kDa transmembrane glycoprotein belonging to the natural cytotoxicity receptor (NCR) family and contains an ITIM domain located in the cytoplasmic tail. Expression of CD336 and NK cell activation by the receptor requires association with DAP12, an ITAM-containing transmembrane accessory protein. Once thought to be expressed exclusively on IL-2-activated NK cells and a subset of gamma delta T lymphocytes, studies have shown expression of CD336 on IL-3-stimulated plasmacytoid dendritic cells, alpha beta T cells in the small intestinal epithelium, and T cells in cord blood. CD336 has been shown to be involved in the innate response of activated NK cells against viral infection and tumor cell proliferation.

Specifications

• Antigen: NCR2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: NCR2
• Gene Alias: CD336, LY95, NK-p44, NKP44, dJ149M18.1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9436
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI4B8
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O95944
• Gene Symbols: NCR2
• Immunogen: Human recombit protein fragment corresponding to amino acids 44-190 of human NCR2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b