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Invitrogen™ NDFIP2 Monoclonal Antibody (2C7)
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Catalog No. PIMA524465
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100 μg
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Catalog No. Quantity
PIMA524465 100 μg
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Catalog No. PIMA524465 Supplier Invitrogen™ Supplier No. MA524465
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Description

Mouse Monoclonal Antibody

Peptide Sequence: MDHHQPGTGR YQVLLNEEDN SESSAIEQPP TSNPAPQIVQ AASSAPALET DSSPPPYSSI TVEVPTTSDT EVYGEFYPVP PPYSVATSLP TYDEAEKAKA AAMAAAAAET SQRIQEEECP PRDDFSDADQ LRVGNDGIFM LAFFMAFIFN WLGFCLSFCI TNTIAGRYGA ICGFGLSLIK WILIVRFSDY FTGYFNGQYW LWWIFLVLGL LLFFRGFVNY LKVRNMSESM AAAHRTRYFF LL.

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen NDFIP2
Applications ELISA, Western Blot
Classification Monoclonal
Clone 2C7
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene NDFIP2
Gene Accession No. Q9NV92
Gene Alias 0710001O20Rik; 2810436B12Rik; 9130207N19Rik; KIAA1165; MAPK-activating protein PM04 PM05 PM06 PM07; mKIAA1165; N4wbp5a; NDFIP2; Nedd4 family interacting protein 2; NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; NF-kappa-B-activating protein 413; putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF-kappa-B-activating protein 413; Unknown (protein for IMAGE:7958216); wu:fa92h03; wu:fk31f07; zgc:63948
Gene Symbols NDFIP2
Host Species Mouse
Immunogen NDFIP2 (AAH21988, 1 a.a. ~ 242 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54602
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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