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Invitrogen™ NDUFAF2 Polyclonal Antibody
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Catalog No. PIPA589734
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100 μL
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PIPA589734 100 μL
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Catalog No. PIPA589734 Supplier Invitrogen™ Supplier No. PA589734
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGWSQDLFRA LWRSLSREVK EHVGTDQFGN KYYYIPQYKN WRGQTIREKR IVEAANKKEV DYEAGDIPTE WEAWIRRTRK TPPTMEEILK NEKHREEIKI KSQDFYEKEK LLSKETSEEL LPPPVQTQIK GHASAPYFGK EEPSVAPSST GKTFQPGSWM PRDGKSHNQ; Positive Samples: HepG2, HeLa, SH-SY5Y, Rat heart; Cellular Location: Mitochondrion.

Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa-B-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NDUFAF2
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Ndufaf2
Gene Accession No. Q59J78, Q8N183
Gene Alias 1810058I14Rik; B17.2L; B17.2-like; B172L; B172-like; C86051; mimitin; mimitin, mitochondrial; MMTN; Myc-induced mitochondria protein; Myc-induced mitochondrial protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NADH dehydrogenase 1 alpha subcomplex assembly factor 2; NADH:ubiquinone oxidoreductase complex assembly factor 2; NDUFA12L; NDUFA12-like protein; Ndufaf2; RGD1560158
Gene Symbols Ndufaf2
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361894, 75597, 91942
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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