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Invitrogen™ NDUFS5 Polyclonal Antibody
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Catalog No. PIPA527542
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100 μL
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PIPA527542 100 μL
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Catalog No. PIPA527542 Supplier Invitrogen™ Supplier No. PA527542
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, Raji. Predicted reactivity: Pig (82%), Chimpanzee (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Located in the mitochondrial inner membrane, mitochondrial complex I is the first and largest enzyme in the electron transport chain of oxidative phosphorylation. By oxidizing NADH that is produced in the Krebs cycle, this complex utilizes the two electrons to reduce ubiquinone to ubiquinol, thereby initiating the passage of electrons to successive complexes and ultimately leading to the reduction of oxygen to water. Mitochondrial complex I consists of over 40 subunits and is of considerable clinical interest since defects in any of the subunits can lead to various myopathies and neuropathies. As a subunit of mitochondrial complex I, NDUFS5 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 5), also designated NADH-ubiquinone oxidoreductase 15 kDa subunit, is a 106 amino acid protein that is suggested to not be involved in catalysis. NDUFS5 is expressed ubiquitously in human tissues, with a relative higher expression in human heart, skeletal muscle, liver, kidney and fetal heart.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NDUFS5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene NDUFS5
Gene Accession No. O43920
Gene Alias AI256693; CI-15 kDa; CI15K; CI-15k; Complex I-15 kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 5b, 15kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; NADH:ubiquinone oxidoreductase 15 kDa IP subunit; NADH:ubiquinone oxidoreductase subunit S5; NADH-ubiquinone oxidoreductase 15 kDa subunit; Ndufs5; Ndufs5b
Gene Symbols NDUFS5
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human NDUFS5. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 362588, 4725
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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