Invitrogen™ Nebulin Monoclonal Antibody (1F4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA519423

Catalog No. PIMA519423

Description

Peptide Sequence: NTKTSYHTPA DMLSVTAAKD AQANITNTNY KHLIHKYILL PDAMNIELTR NMNRIQSDNE YKQDYNEWYK GLGWSPAGSL EVEKAKKATE YASDQKYRQH PSNFQFKKLT.

This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kDa due to alternative splicing that is tissue-, species-, and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Mutations in this gene are associated with recessive nemaline myopathy.

Specifications

• Antigen: Nebulin
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: P20929
• Gene Symbols: NEB
• Immunogen: NEB (NP_004534, 2108 a.a. ~ 2217 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Western Blot
• Clone: 1F4
• Conjugate: Unconjugated
• Gene: NEB
• Gene Alias: AI595938; DKFZp686C1456; FLJ11505; FLJ36536; FLJ39568; FLJ39584; NEB; NEB177D; nebulin; NEM2; nemaline myopathy type 2
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4703
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid