Invitrogen™ Nebulin Monoclonal Antibody (NB2)

Catalog No.	Quantity
PIMA549308	100 μg

Catalog No. PIMA549308 Supplier Invitrogen™ Supplier No. MA549308

Description

Mouse Monoclonal Antibody

Adding 1 mL of PBS buffer will yield a concentration of 100 μg/mL. Positive Control - WB: Mouse Skeletal Muscle Tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kDa due to alternative splicing that is tissue-, species-, and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Mutations in this gene are associated with recessive nemaline myopathy.

Specifications

• Antigen: Nebulin
• Applications: Western Blot
• Classification: Monoclonal
• Clone: NB2
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: Ascites, 1.2% sodium acetate with 2mg BSA and 0.01mg sodium azide
• Gene: NEB
• Gene Accession No.: Q99439
• Gene Alias: AI595938; DKFZp686C1456; FLJ11505; FLJ36536; FLJ39568; FLJ39584; NEB; NEB177D; nebulin; NEM2; nemaline myopathy type 2
• Gene Symbols: NEB
• Host Species: Mouse
• Immunogen: Chicken breast nebulin.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 374027
• Target Species: Chicken
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1