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Invitrogen™ Nectin 4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5101754
Description
Antibody detects endogenous levels of total PVRL4.
Nectin 4 (PVRL4) is a gene located on chromosome 1q23.3 that encodes a member of the nectin family of cellular adhesion molecules. These proteins are primarily involved in forming adherens junctions between epithelial cells, contributing to tissue integrity and maintenance in various tissues, including the skin, lungs, and mammary glands. Nectin 4 is highly expressed during embryonic development and is crucial for processes like tissue morphogenesis and repair. It acts as a ligand for the poliovirus receptor-related family and participates in cell signaling pathways that influence cell proliferation and survival. In the context of cancer, Nectin 4 is often upregulated, particularly in breast, ovarian, and lung cancers, where its expression is associated with tumor progression, metastasis, and poor prognosis. This makes Nectin 4 a potential target for therapeutic interventions and a candidate biomarker for cancer diagnosis and monitoring.
Specifications
Nectin 4 | |
Polyclonal | |
Unconjugated | |
NECTIN4 | |
1200017F15Rik; EDSS1; ig superfamily receptor LNIR; LNIR; nectin 4; nectin cell adhesion molecule 4; NECTIN4; Nectin-4; poliovirus receptor-related 4; poliovirus receptor-related protein 4; Processed poliovirus receptor-related protein 4; PRR4; Pvrl4; RGD1559826 | |
Rabbit | |
Affinity chromatography | |
RUO | |
71740, 81607 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q8R007, Q96NY8 | |
NECTIN4 | |
A synthesized peptide derived from human NECTIN4(Accession Q96NY8), corresponding to amino acid residues G311-F361. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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