Invitrogen™ Nectin 4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101754

Catalog No. PIPA5101754

Description

Antibody detects endogenous levels of total PVRL4.

Nectin 4 (PVRL4) is a gene located on chromosome 1q23.3 that encodes a member of the nectin family of cellular adhesion molecules. These proteins are primarily involved in forming adherens junctions between epithelial cells, contributing to tissue integrity and maintenance in various tissues, including the skin, lungs, and mammary glands. Nectin 4 is highly expressed during embryonic development and is crucial for processes like tissue morphogenesis and repair. It acts as a ligand for the poliovirus receptor-related family and participates in cell signaling pathways that influence cell proliferation and survival. In the context of cancer, Nectin 4 is often upregulated, particularly in breast, ovarian, and lung cancers, where its expression is associated with tumor progression, metastasis, and poor prognosis. This makes Nectin 4 a potential target for therapeutic interventions and a candidate biomarker for cancer diagnosis and monitoring.

Specifications

• Antigen: Nectin 4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NECTIN4
• Gene Alias: 1200017F15Rik; EDSS1; ig superfamily receptor LNIR; LNIR; nectin 4; nectin cell adhesion molecule 4; NECTIN4; Nectin-4; poliovirus receptor-related 4; poliovirus receptor-related protein 4; Processed poliovirus receptor-related protein 4; PRR4; Pvrl4; RGD1559826
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 71740, 81607
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8R007, Q96NY8
• Gene Symbols: NECTIN4
• Immunogen: A synthesized peptide derived from human NECTIN4(Accession Q96NY8), corresponding to amino acid residues G311-F361.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov