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NEDD4 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 216981AP

Catalog No. 50-173-3552


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Description

Description

This antibody can recognize NEDD4-1 and NEDD4-2.

The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.
Specifications

Specifications

NEDD4
0.22 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P46934, P46935, Q62940
KIAA0093, NEDD 4, NEDD4, NEDD4 1, RPF1
Rabbit
IgG
150 μL
-20°C
Primary
17999, 25489, 4734
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
NEDD4
Liquid
Nedd4
NEDD4 Fusion Protein Ag16291
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Rat
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