NEDD4 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 216981AP
This antibody can recognize NEDD4-1 and NEDD4-2.The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P46934, P46935, Q62940|
|KIAA0093, NEDD 4, NEDD4, NEDD4 1, RPF1|
|17999, 25489, 4734|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|NEDD4 Fusion Protein Ag16291|
|Antigen Affinity Chromatography|
|Human, Mouse, Non-human primate, Rat|
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