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Invitrogen™ NEDD4L Polyclonal Antibody
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Catalog No. PIPA579726
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100 μg
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Catalog No. Quantity
PIPA579726 100 μg
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Catalog No. PIPA579726 Supplier Invitrogen™ Supplier No. PA579726
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human 22RV1 whole cell, human Jurkat whole cell, rat pancreas tissue, mouse pancreas tissue, mouse NIH3T3 whole cell. Flow: U20S cell.

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NEDD4L
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation Antibody with 0.2mg Na2PO4, 0.9mg NaCl, 4mg trehalose and 0.05mg sodium azide
Gene NEDD4L
Gene Accession No. Q8CFI0, Q96PU5
Gene Alias 1300012C07Rik; E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; hNEDD4-2; KIAA0439; NEDD4; NEDD4 like E3 ubiquitin protein ligase; NEDD4.2; Nedd4-2; nedd4b; NEDD4L; NEDL3; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4b; neural precursor cell expressed, developmentally down-regulated gene 4-like; RSP5; ubiquitin-protein ligase Nedd4-2; ubiquitin-protein ligase Rsp5; Unknown (protein for IMAGE:7986262)
Gene Symbols NEDD4L
Host Species Rabbit
Immunogen E. coli-derived human NEDD4-2 recombinant protein (Position: N703-D975).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23327, 291553, 83814
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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