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Invitrogen™ NEDD4L Recombinant Rabbit Monoclonal Antibody (3W9J2)
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Catalog No. PIMA542908
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100 μL
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PIMA542908 100 μL
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Catalog No. PIMA542908 Supplier Invitrogen™ Supplier No. MA542908
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: HeLa, K-562. Immunogen sequence: NHPVIQWFWK AVLLMDAEKR IRLLQFVTGT SRVPMNGFAE LYGSNGPQLF TIEQWGSPEK LPRAHTCFNR LDLPPYETFE DLREKLLMAV ENAQGFEGVD.

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NEDD4L
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 3W9J2
Concentration 0.75 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NEDD4L
Gene Accession No. Q96PU5
Gene Alias 1300012C07Rik; E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; hNEDD4-2; KIAA0439; NEDD4; NEDD4 like E3 ubiquitin protein ligase; NEDD4.2; Nedd4-2; nedd4b; NEDD4L; NEDL3; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4b; neural precursor cell expressed, developmentally down-regulated gene 4-like; RSP5; ubiquitin-protein ligase Nedd4-2; ubiquitin-protein ligase Rsp5; Unknown (protein for IMAGE:7986262)
Gene Symbols NEDD4L
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 876-975 of human NEDD4L (Q96PU5).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23327
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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