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NEDD9 Mouse anti-Human, Clone: OTI3H4, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF809513

Encompass_Preferred

Catalog No. 50-166-9549


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.
Specifications

Specifications

NEDD9
Monoclonal
Unconjugated
NEDD9
CAS-L, CAS2, CASL, CASS2, HEF1
Mouse
Affinity Chromatography
RUO
4739
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI3H4
PBS with 8% trehalose and no preservative; pH 7.3
Q14511
NEDD9
Full length human recombit protein of human NEDD9 produced in HEK293T cell.
100 μg
Primary
Human
Antibody
IgG1
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