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NEDD9 Mouse anti-Human, Clone: OTI6E3, lyophilized, TrueMAB™
SDP

Catalog No. 501669548
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100 μg
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50-166-9548 100 μg
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Catalog No. 50-166-9548 Supplier OriGene Supplier No. CF809512
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.

Specifications

Antigen NEDD9
Applications Western Blot
Classification Monoclonal
Clone OTI6E3
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene NEDD9
Gene Accession No. Q14511
Gene Alias CAS-L, CAS2, CASL, CASS2, HEF1
Gene Symbols NEDD9
Host Species Mouse
Immunogen Full length human recombit protein of human NEDD9 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4739
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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