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Invitrogen™ NEIL3 Polyclonal Antibody
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Catalog No. PA550028
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100 μL
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PA550028 100 μL
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Catalog No. PA550028 Supplier Invitrogen™ Supplier No. PA550028
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total NEIL3 protein.

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NEIL3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 30% glycerol, 0.87% NaCl and 0.01% sodium azide; pH 7.4
Gene Neil3
Gene Accession No. Q8K203, Q8TAT5
Gene Alias AI449477; BC034753; C85903; DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; Endonuclease 8-like 3; endonuclease VIII-like 3; FGP2; FLJ10858; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3; nei endonuclease VIII-like 3 (E. coli); nei like 3; nei like 3 (E. coli); nei like DNA glycosylase 3; NEI3; Neil3; nei-like DNA glycosylase 3; nei-like protein 3; RGD1310562; ZGRF3; zinc finger, GRF-type containing 3
Gene Symbols Neil3
Host Species Rabbit
Immunogen Synthesized peptide derived from internal of human NEIL3.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 234258, 290729, 55247
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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