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Invitrogen™ NEK3 Polyclonal Antibody
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Catalog No. PIPA560284
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100 μL
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PIPA560284 100 μL
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Catalog No. PIPA560284 Supplier Invitrogen™ Supplier No. PA560284
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RGGSVIKYSK NTTRKQWLKE TPDTLLNILK NADLSLAFQT YTIYRPGSEG FLKGPLSEET EASDSVDGGH DSVILDPERL EPGLDEED Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 74%.

NIMA was originally shown in Aspergillus nidulans to be necessary for entry into mitosis. NIMA-related mammalian proteins have since been identified as Nek1, Nek2, Nek3 and Nek4 (also designated STK2 or NRK2). High expression of Nek1 is seen in male and female germ cell lines of mouse. Nek2 is the closest known mammalian relative to NIMA. Like NIMA, Nek2 expression peaks at the G2 to M phase transition. Nek3 is a predominantly cytoplasmic enzyme that was detectable in all organs studied. Levels of Nek3 seem to remain unchanged throughout the cell cycle, but appear to be elevated in G0-arrested, quiescent fibroblasts. In developing testicular germ cells, differential patterns of expression were seen for Nek1, Nek2 and Nek4, indicating possible overlapping, but non-identical functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NEK3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Nek3
Gene Accession No. P51956
Gene Alias glycogen synthase A kinase; HSPK 36; HSPK36; hydroxyalkyl-protein kinase; Nek3; Never in mitosis A-related kinase 3; NIMA (never in mitosis gene a)-related expressed kinase 3; NIMA (never in mitosis gene a)-related kinase 3; NIMA related kinase 3; NIMA-related expressed kinase 3; NIMA-related kinase 3; nimA-related protein kinase 3; phosphorylase B kinase kinase; serine/threonine-protein kinase Nek3
Gene Symbols Nek3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human NEK3. Recombinant protein control fragment (Product #RP-99574).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4752
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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