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NEK4 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501563183
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50-156-3183 20 μL
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Catalog No. 50-156-3183 Supplier Bethyl Laboratories, Inc Supplier No. A302673AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Specifications

Antigen NEK4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene NEK4
Gene Accession No. P51957
Gene Alias Serine/threonine-protein kinase Nek4, NimA-related protein kinase 4, Serine/threonine protein kinase 2, Serine/threonine-protein kinase NRK2
Gene Symbols NEK4
Host Species Rabbit
Immunogen Between 475 and 525
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6787
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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