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NEK8 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA529422
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PIPA529422 100 μL
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Catalog No. PIPA529422 Supplier Thermo Scientific Supplier No. PA529422

Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (89%), Xenopus laevis (93%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

NEK8 serine/threonine kinase or NIMA-related kinase 8 is related to NIMA (never in mitosis, gene A) of Aspergillus nodulins and may play a role in cell cycle progression from G2 to M phase. NEK8 is part of a complex of ciliary proteins required for renal and cardiovascular development. NEK8 interacts with polycystin signal transduction pathways and may control the targeting of these ciliary proteins. Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia.Defects in NEK8 are the cause of nephronophthisis type 9 (NPHP9) [MIM:613824]. NPHP9 is an autosomal recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NEK8
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene NEK8
Gene Accession No. Q86SG6
Gene Alias 4632401F23Rik; b2b1449Clo; JCK; juvenile cystic kidney; NEK 8; NEK12A; Nek8; nephrocystin 9; never in mitosis A-related kinase 8; NIMA (never in mitosis gene a)- related kinase 8; NIMA (never in mitosis gene a)-related expressed kinase 8; NIMA related kinase 8; NIMA-family kinase NEK8; NIMA-related expressed kinase 8; NIMA-related kinase 12a; NIMA-related kinase 8; nima-related protein kinase 12a; NimA-related protein kinase 8; NPHP9; RHPD2; Serine/threonine-protein kinase Nek8; serine/thrionine-protein kinase NEK8
Gene Symbols NEK8
Host Species Rabbit
Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 214 of Human NEK8
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 284086
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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