NEMO/IKK-gamma Polyclonal Antibody, Rockland™

Rabbit Polyclonal Antibody

Supplier:  Rockland Immunochemicals 200401GM7

Catalog No. 50-194-3810

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Anti-NEMO is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. This antibody detects human NEMO. Cross reactivity with NEMO from other sources is unknown.

IKK gamma is the regulatory subunit of the inhibitor of the kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

Specifications

• Antigen: NEMO/IKK-gamma
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ikbkg
• Gene Alias: 1110037D23Rik; AI848108; AI851264; AMCBX1; AW124339; FIP3; FIP-3; Fip3p; I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; IkB kinase-associated protein 1; Ikbkg; IKK[g]; IKK3; IKKAP1; IKKG; IKK-gamma; IMD33; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; mF; mFIP-3; NEMO; NF-kappa B essential modulator; NF-kappa-B essential modifier; NF-kappa-B essential modulator; OTTHUMP00000207079; OTTHUMP00000212188; ZC2HC9
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody

• Applications: ELISA, Immunoprecipitation, Western Blot
• Concentration: 1.1 mg/mL
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6K9
• Gene Symbols: Ikbkg
• Immunogen: Anti-NEMO was affinity purified from whole rabbit serum prepared by repeated immunizations with a recombinant protein of human NEMO.
• Regulatory Status: RUO
• Gene ID (Entrez): 8517
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid