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Invitrogen™ Nephrin Monoclonal Antibody (C8)
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Catalog No. PIMA541644
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200 μL
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Catalog No. Quantity
PIMA541644 200 μL
PIMA543718 20 μL
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Catalog No. PIMA541644 Supplier Invitrogen™ Supplier No. MA541644
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Description

Mouse Monoclonal Antibody

Nephrin Monoclonal Antibody for Western Blot, ICC/IF

Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2. Nephrin, a recently identified protein is a member of a group of podocyte proteins that constitute major component of the slit diaphragm especially in the foot process. Nephrin, a cell adhesion molecule, may play a crucial role in maintaining the glomerular filtration barrier. Recent studies have suggested that mutations in the gene for Nephrin reportedly lead to congenital nephrosis. Three novel podocyte proteins, Podocin, Nephrin and alpha Actinin 4 have been identified in congenital and experimental models of proteinuria. The role of Nephrin in anti apoptotic activity in podocyte slit diaphragm is believed to be associated with vascular endothelial derived growth factors VEGF signaling. Nephrin seems to play a role in the development or function of the kidney glomerular filtration barrier and it may anchor the podocyte slit diaphragm to the actin cytoskeleton.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nephrin
Applications Western Blot, Immunocytochemistry, Western Blot
Classification Monoclonal
Clone C8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene Nphs1
Gene Accession No. O60500
Gene Alias CNF; Nephrin; nephrin 1; NephrinB; nephrosis 1 homolog, nephrin; nephrosis 1, congenital, Finnish type (nephrin); nephrosis 1, nephrin; NPHN; NPHS1; NPHS1 nephrin; NPHS1, nephrin; renal glomerulus-specific cell adhesion receptor
Gene Symbols Nphs1
Host Species Mouse
Immunogen Recombinant protein Nephrin. The antigen corresponds to amino acid range 27-234 of the target protein.
Purification Method Protein A/G
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4868
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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