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  5. Tocris Bioscience™ Nepicastat hydrochloride

Tocris Bioscience™ Nepicastat hydrochloride
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Catalog No. 503750RD
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50-375-0RD 50 mg
50-371-0RD 10 mg
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Catalog No. 50-375-0RD Supplier Tocris Bioscience™ Supplier No. 5037/50
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Description

Potent and selective dopamine β-hydroxylase (DBH) inhibitor; orally bioavailable

Nepicastat hydrochloride is a potent and selective dopamine β-hydroxylase (DBH) inhibitor (IC50 = 9 nM) . Selective for DBH over 12 other enzymes. Decreases noradrenaline and increases dopamine levels in tissues and plasma in hypertensive rats. Prevents progressive left ventricular dysfunction in an in vivo heart failure model. Also potentiates the stimulus effects of cocaine without producing cocaine-like effects in rats. Orally bioavailable.

Specifications

Chemical Name or Material 5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride
CAS 170151-24-3
Quantity 50 mg
Target Hydroxylase Inhibitors
Molecular Formula C14H15F2N3S.HCl
Formula Weight 331.81
Purity >98%
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