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  5. Tocris Bioscience™ NESS 0327

Tocris Bioscience™ NESS 0327
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Catalog No. 574610
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10 mg
50 mg
Catalog No. Quantity
57-461-0 10 mg
57-465-0 50 mg
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Catalog No. 57-461-0

Supplier: Tocris Bioscience™ 5746/10

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Description

Ultra-high affinity and selective CB1 antagonist

NESS 0327 is an ultra-high affinity and selective CB1 receptor antagonist (Ki = 350 fM). Exhibits >60-fold selectivity for CB1 over CB2 receptors. Antagonizes the inhibitory effects of WIN 55,212-2 (Cat. No. 1038) on electrically evoked contractions in mouse isolated vas deferens ex vivo. Also antagonizes the antinociceptive effect of WIN 55,212-2 in tail-flick and hot plate tests in vivo.

Specifications

Chemical Name or Material 8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7 ]cyclohepta[1,2-c]pyrazole-3-carboxamide
CAS 494844-07-4
Quantity 10 mg
Target Cannabinoid R1/CB1 Antagonists
Molecular Formula C24H23Cl3N4O
Formula Weight 1970
Purity 98%
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