Invitrogen™ Nestin Monoclonal Antibody (10C2), HRP

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA516105

Catalog No. PIMA516105

Description

This antibody does not cross-react with rodent or rabbit.

Nestin is a Class VI intermediate filament abundantly produced in the developing central nervous system (CNS) and in early embryonic neuroepithelial stem cells. Nestin has been widely used as a predominant marker for stem/progenitor cells, glioma cells, and tumor endothelial cells. Also, Nestin is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumors. Highly specific antibodies to human Nestin can aid in characterizing progenitor cells differentiating into distinct lineages, in enhancing the therapeutic potential of human neural stem/progenitor cells in the treatment of CNS diseases or injury, and in identifying neuroepithelial tumor cells. Nestin expression has been observed in pancreatic hematopoietic stem cell populations, and is considered a novel angiogenesis marker of proliferating endothelial cells in colorectal cancer tissue.

Specifications

• Antigen: Nestin
• Classification: Monoclonal
• Concentration: 2.23 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P48681
• Gene Symbols: Nes
• Immunogen: A fragment of the human nestin protein corresponding to residues 1464-1614.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Clone: 10C2
• Conjugate: HRP
• Gene: Nes
• Gene Alias: AA166324; C78523; ESTM46; FLJ21841; intermediate filament protein; Nbla00170; Nes; Nestin
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 10763
• Content And Storage: 4°C, store in dark
• Form: Liquid