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Invitrogen™ Nestin Monoclonal Antibody (2Q178)
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Catalog No. PIMA191657
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50 μg
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Catalog No. Quantity
PIMA191657 50 μg
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Catalog No. PIMA191657 Supplier Invitrogen™ Supplier No. MA191657
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Description

Mouse Monoclonal Antibody

For use in ICC applications, cells can be fixed with 4% paraformaldehyde buffered with 50mM sodium borate at p.H. 9.5. for IHC-P and IHC-Fr tissue can be fixed with 4% paraformaldehyde at pH 7.4 for light microscopy. The predicted molecular weight of MA1-91657 is ~200kDa.

Nestin is a Class VI intermediate filament abundantly produced in the developing central nervous system (CNS) and in early embryonic neuroepithelial stem cells. Nestin has been widely used as a predominant marker for stem/progenitor cells, glioma cells, and tumor endothelial cells. Also, Nestin is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumors. Highly specific antibodies to human Nestin can aid in characterizing progenitor cells differentiating into distinct lineages, in enhancing the therapeutic potential of human neural stem/progenitor cells in the treatment of CNS diseases or injury, and in identifying neuroepithelial tumor cells. Nestin expression has been observed in pancreatic hematopoietic stem cell populations, and is considered a novel angiogenesis marker of proliferating endothelial cells in colorectal cancer tissue.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nestin
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2Q178
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% sodium azide
Gene Nes
Gene Accession No. P21263, Q6P5H2
Gene Alias AA166324; C78523; ESTM46; FLJ21841; intermediate filament protein; Nbla00170; Nes; Nestin
Gene Symbols Nes
Host Species Mouse
Immunogen Nestin purified from embryonic rat spinal cord.
Purification Method IgG fraction
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100761741, 18008, 25491, 395890, 490410
Target Species Mouse, Rat, Canine, Hamster, Chicken
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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