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Neuritin Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984751
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100 μL
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Catalog No. Quantity
50-198-4751 100 μL
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Catalog No. 50-198-4751 Supplier Bioss Supplier No. BS2464R
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Description

Rabbit Polyclonal Antibody

As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.

Specifications

Antigen Neuritin
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene NRN1
Gene Accession No. Q9NPD7
Gene Alias 0710008J23Rik; Candidate plasticity gene 15 protein; candidate plasticity-related gene 15; Cpg15; dJ380B8.2; Neuritin; neuritin 1; NRN; Nrn1
Gene Symbols NRN1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Nrn1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51299
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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