Neurocan, Rabbit anti-Rat, Polyclonal, Millipore Sigma™

Catalog No.	Quantity
ABT138225UL	25 μL

Catalog No. ABT138225UL Supplier MilliporeSigma Supplier No. ABT138225UL

Description

Rabbit Polyclonal Antibody

This rabbit polyclonal Anti-Neurocan, Cat. No. ABT1382, is a rabbit polyclonal antibody that detects Neurocan core protein and has been tested for use in Immunofluorescence.

Neurocan core protein (UniProt: P55067; also known as 245 kDa early postnatal core glycoprotein, Chondroitin sulfate proteoglycan 3) is encoded by the Ncan (also known as Cspg3) gene in rat. Neurocan is a secreted protein of the aggrecan/versican proteoglycan family that is found in early postnatal and adult brain. During early postnatal development neurocan accounts for at least 20% of the protein of the soluble brain proteoglycans. Neurocan mostly contains chondroitin sulfate, but also has N-linked and O-linked oligosaccharides. It is shown to be involved in the modulation of cell adhesion and migration and regulates neurite outgrowth. Neurocan interact with several cell surface molecules, such as N-CAM, L1/Ng-CAM, etc., and modulates the cell-binding and neurite outgrowth promoting activates of these molecules. Neurocan is synthesized with a 22 aa signal peptide that is subsequently cleaved to produce the mature form. Neurocan contains one C-type lectin domain, two EGF-like domains, one Ig-like V type domain, two link domains and one Sushi (CCP/SCR) domain. (Ref.: Rauch, U., et al. (2001) Cell Mol. Life Sci. 58(12-13):1842-56; Zhou, XH et al. (2001). Mol. Cell Biol. 21(17): 5970-78).

Specifications

• Antigen: Neurocan
• Applications: Immunofluorescence
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide.
• Gene Alias: Neurocan core protein;245 kDa early postnatal core glycoprotein;Chondroitin sulfate proteoglycan 3
• Gene Symbols: Ncan;Cspg3
• Host Species: Rabbit
• Immunogen: Full-length Neurocan isolated from 7-day embryonic rat brain and purified by monoclonal antibody immunoaffinity chromatography.
• Molecular Weight of Antigen: 135.55 kDa calculated.
• Purification Method: Unpurified
• Quantity: 25 μL
• Regulatory Status: RUO
• Research Discipline: Cell Structure
• Primary or Secondary: Primary
• Test Specificity: This rabbit polyclonal antibody detects Neurocan in fetal and adult rat brain.
• Target Species: Rat
• Content And Storage: Stable for 1 year at -20°C from date of receipt.
• Isotype: IgG