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Invitrogen™ NeuroD1 Polyclonal Antibody
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Catalog No. PIPA588138
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100 μL
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PIPA588138 100 μL
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Catalog No. PIPA588138 Supplier Invitrogen™ Supplier No. PA588138
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GKSPDLVSFV QTLCKGLSQP TTNLVAGCLQ LNPRTFLPEQ NQDMPPHLPT ASASFPVHPY SYQSPGLPSP PYGTMDSSHV FHVKPPPHAY SAALEPFFES PLTDCTSPSF DGPLSPPLSI NGNFSFKHEP SAEFEKNYAF TMHYPAATLA GAQSHGSIFS GTAAPRCEIP IDNIMSFDSH SHHERVMSAQ LNAIFHD Positive Samples: HepG2, Mouse brain; Cellular Location: Cytoplasm, Nucleus.

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NeuroD1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.44 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NEUROD1
Gene Accession No. Q13562, Q64289
Gene Alias Basic helix-loop-helix factor 1; basic helix-loop-helix transcription factor; Beta2; beta-cell E-box transactivator 2; beta-cell E-box transcriptional activator 2; BHF1; BHF-1; bHLHa3; Class A basic helix-loop-helix protein 3; MODY6; neuro d1; Neurod; Neurod1; neurogenic differentiation 1; neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD; neuronal differentiation 1
Gene Symbols NEUROD1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 160-356 of human NEUROD1 (NP_0024912).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29458, 4760
Target Species Human, Rat, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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