Invitrogen™ Neurofascin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578668

Catalog No. PIPA578668

Description

Positive Control: mouse brain, rat brain Predicted Reactivity: Human (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Neurofascin encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. Neurofascin undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

Specifications

• Antigen: Neurofascin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NFASC
• Gene Alias: AA387016; D430023G06Rik; DKFZp686P2250; KIAA0756; KIAA0756FLJ46866; mKIAA0756; neurofascin; neurofascin homolog; NF; Nfasc; NRCAML
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116690, 269116
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.14 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P97685, Q810U3
• Gene Symbols: NFASC
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of mouse Neurofascin. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov