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Invitrogen™ Neurogenin 1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA591933
Description
Positive Samples: SH-SY5Y, THP-1, U-87MG, HepG2, Mouse testis; Cellular Location: Nucleus Immunogen sequence: MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH.
Neurogenin 1 is a basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.
Specifications
Neurogenin 1 | |
Polyclonal | |
Unconjugated | |
NEUROG1 | |
AKA; ATH4C; basic helix-loop-helix transcription factor; bHLHa6; cb260; chunp6899; class A basic helix-loop-helix protein 6; Helix-loop-helix protein mATH-4C; Math4C; Neurod3; NEUROG1; Neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; neurogenic differentiation factor 3; neurogenin; neurogenin 1; neurogenin related protein-1; neurogenin-1; Neurogenin-related protein 1; NGN; Ngn1; NGN-1; ngr1; transcription factor; Zath4c; zNgn1 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
18014, 4762 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Western Blot | |
0.28 mg/mL | |
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3 | |
P70660, Q92886 | |
NEUROG1 | |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human NEUROG1 (Q92886). | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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