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MilliporeSigma™ Neurogenin-2, Mouse, Unlabeled, Clone: 7G4,

Catalog No. MABN1814MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABN1814MI 100 μg Unconjugated
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Catalog No. MABN1814MI Supplier MilliporeSigma™ Supplier No. MABN1814
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Description

Mouse Monoclonal Antibody

Neurogenin-2 (UniProt P70447; also known as Helix-loop-helix protein mATH-4A, mATH4A, NGN-2, Protein atonal homolog 4) is encoded by the Neurog2 (also known as Ath4a, Atoh4, Ngn2) gene (Gene ID 11924) in murine species. Neuronal differentiation is largely under the control of basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key roles during development of the embryonic nervous system. Neurogenin-2 (NGN-2) is a bHLH proneural transcription factor that orchestrates the progression from neural progenitor to differentiating neuron in several regions of the central nervous system, including the formation of sensory neurons from the epibranchial placode and neurogenesis in dorsal root ganglia. NGN-2 dimerizes with TCF3 (E12/E47), the heterodimer then binds to target DNA regions and recruit transcriptional coactivators, such as p300/CBP and Brg1, to facilitate the transcription of a cascade of additional bHLH transcription factors, such as NeuroD, as well as structural and functional genes associated with mature neuronal activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Neurogenin-2
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 7G4
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Neurog2, Ath4a, Atoh4, Ngn2
Gene Accession No. P70447
Host Species Mouse
Immunogen GST-tagged mouse neurogenin-2 N-terminal fragment (Lo, L., et al. (2002). Development. 129(7):1553-1567).
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_033848
Test Specificity The specific staining by clone 7G4 was blocked by NGN2-GST fusion, but not by NGN1-fusion protein (Lo, L., et al. (2002). Development. 129(7):1553-1567).
Target Species Mouse
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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For Research Use Only. Not for use in diagnostic procedures.

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