Neurokinin B receptor Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-0109	100 μL

Catalog No. 50-198-0109 Supplier Bioss Supplier No. BS0166R

Description

Rabbit Polyclonal Antibody

The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B. NK3R antibody does not recognize NK1R or NK2R.

Specifications

• Antigen: Neurokinin B receptor
• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Tacr3
• Gene Accession No.: P29371
• Gene Alias: G protein-coupled receptor; HH11; neurokinin 3 receptor; Neurokinin B; Neurokinin B receptor; neurokinin beta receptor; neuromedin K receptor; Neuromedin K receptor (Neurokinin B/Tachikin 3); Neuromedin-K receptor; NK3 receptor; NK-3 receptor; NK3R; NK-3R; NK3R TAC3R; NKR; Nmkr; Nmk-r; Tac3r; TAC3RL; tachikin receptor 3; Tachykinin receptor 3; Tacr3
• Gene Symbols: Tacr3
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human NKR.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6870
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG