Invitrogen™ Neuropilin 1 Monoclonal Antibody (8G6G7)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549195

Catalog No. PIMA549195

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Human Neuropilin 1 shares 95% and 94% amino acid (aa) sequences identity with mouse and rat Neuropilin 1, respectively. Positive Control - WB: human placenta tissue, human U-87MG whole cell, human PC-3 whole cell, human MCF-7 whole cell, rat stomach tissue. ICC/IF: A549 cell. Flow: U87 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.

Specifications

• Antigen: Neuropilin 1
• Classification: Monoclonal
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: O14786, Q9QWJ9
• Gene Symbols: NRP1
• Immunogen: E.coli-derived human Neuropilin 1 recombinant protein (Position: K504-T827).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: 8G6G7
• Conjugate: Unconjugated
• Gene: NRP1
• Gene Alias: A5 protein; BDCA4; C530029I03; CD304; Neuropilin; neuropilin 1; Neuropilin1; neuropilin-1; Neuropilin-1 precursor (A5 protein); NP1; NP-1; Npn1; NPN-1; NRP; NRP 1; Nrp1; sNRP 1; sNRP1; soluble NRP 1; soluble NRP1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; VEGF165R
• Host Species: Mouse
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 246331, 8829
• Content And Storage: -20°C
• Form: Lyophilized