Invitrogen™ Neuropoietin Monoclonal Antibody (321525)

Catalog No.	Quantity
PIMA524044	100 μg

Catalog No. PIMA524044 Supplier Invitrogen™ Supplier No. MA524044

Description

Rat Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex formed of a CNTF receptor-alpha component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons, and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human neuropoietin gene has evolved toward a pseudogene, suggesting that alternative signaling via CNTF is an effective compensatory pathway.

Specifications

• Antigen: Neuropoietin
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 321525
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: Ctf2
• Gene Accession No.: P83714
• Gene Alias: cardiotrophin 2; cardiotrophin-2; CT-2; Ctf2; CTF2P; Gm494; Neuropoietin; Np
• Gene Symbols: Ctf2
• Host Species: Rat
• Immunogen: E. coli-derived recombinant mouse Neuropoietin/NP Ala23-Ala204.
• Purification Method: Protein A/G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 244218
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1