Invitrogen™ Neuropoietin Monoclonal Antibody (321525)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA524044

Catalog No. PIMA524044

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex formed of a CNTF receptor-alpha component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons, and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human neuropoietin gene has evolved toward a pseudogene, suggesting that alternative signaling via CNTF is an effective compensatory pathway.

Specifications

• Antigen: Neuropoietin
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P83714
• Gene Symbols: Ctf2
• Immunogen: E. coli-derived recombinant mouse Neuropoietin/NP Ala23-Ala204.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: 321525
• Conjugate: Unconjugated
• Gene: Ctf2
• Gene Alias: cardiotrophin 2; cardiotrophin-2; CT-2; Ctf2; CTF2P; Gm494; Neuropoietin; Np
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 244218
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized