Invitrogen™ Neurotrypsin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557133

Catalog No. PIPA557133

Description

Immunogen sequence: WVSVTDFGAP CLRWAEVPPF LERSPPASWA QLRGQRHNFC RSPDGAGRPW CFYGDARGKV DWGYCDCRHG SVRLRGGK Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 72%.

Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.

Specifications

• Antigen: Neurotrypsin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRSS12
• Gene Alias: Brain-specific serine protease 3; Bssp3; BSSP-3; leydin; Motopsin; MRT1; Neurotrypsin; Nt; peptidase, serine, 12 (neurotrypsin, motopsin); protease, serine 12; protease, serine 12 neurotrypsin (motopsin); protease, serine, 12 (neurotrypsin, motopsin); protease, serine, 12 neurotrypsin (motopsin); Prss12; Serine protease 12
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8492
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P56730
• Gene Symbols: PRSS12
• Immunogen: Recombinant protein corresponding to Human Neurotrypsin. Recombinant protein control fragment (Product #RP-102646).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov