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Tocris Bioscience™ Nexinhib20

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Quantity:
5 mg
25 mg
Description
Nexinhib20 is a Rab27 inhibitor (IC50 = 330 nM); inhibits Rab27a-JFC1 binding. Selectively inhibits neutrophil exocytosis, with no significant effect on other important innate immune responses including phagocytosis. Suppresses extracellular production of superoxide anion and cytochrome b plasma membrane expression. Also inhibits upregulation of adhesion molecules CD11b and CD66b. Displays in vivo anti-inflammatory activity.
Specifications
Specifications
Chemical Name or Material | 4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one |
CAS | 331949-35-0 |
Quantity | 25 mg |
Molecular Formula | C15H16N4O3 |
Formula Weight | 300.31 |
Purity | 98% |
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