| Antigen |
NF-L |
| Applications |
Immunohistochemistry (Paraffin), Immunofluorescence |
| Classification |
Monoclonal |
| Clone |
NFL/736 |
| Concentration |
1.0 mg/mL |
| Conjugate |
Unconjugated |
| Dilution |
Immunohistochemistry-Paraffin : 0.25 - 0.5 ug/ml, Immunofluorescence : 1 - 2 ug/ml |
| Formulation |
PBS with No Preservative |
| Gene Alias |
68 kDa neurofilament protein, neurofilament protein, light chain, neurofilament subunit NF-L, Neurofilament triplet L protein, neurofilament, light polypeptide, neurofilament-light, NF68FLJ53642, NF-L, NFLlight polypeptide 68kDa |
| Gene Symbols |
NEFL |
| Host Species |
Mouse |
| Immunogen |
Recombinant human NEFL protein |
| Molecular Weight of Antigen |
68 kDa |
| Purification Method |
Protein A or G purified |
| Quantity |
0.1 mg |
| Regulatory Status |
RUO |
| Research Discipline |
Autophagy, Cellular Markers, Cytoskeleton Markers, Neurodegeneration, Neurofilaments, Neuronal Cell Markers, Neuroscience |
| Primary or Secondary |
Primary |
| Gene ID (Entrez) |
4747 |
| Test Specificity |
This MAb reacts with a 68kDa protein, identified as light sub-unit of neurofilaments (NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament. |
| Target Species |
Human, Rat, Pig, Chicken, Primate |
| Content And Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Form |
Purified |
| Isotype |
IgG1 |
|
Show More
Show Less
|
|