NF Mouse anti-Human, Clone: OTI3F7, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF190077

Catalog No. 50-165-9210

Description

Synthetic peptide sequence is EYQDLLNVKMALDIEIAAYRKLLEGEE Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Diseases associated with NEFM include Pineal Parenchymal Tumor Of Intermediate Differentiation and Wallerian Degeneration. Among its related pathways are Amyotrophic lateral sclerosis (ALS) and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton.

Specifications

• Antigen: NF
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: NEFL
• Gene Alias: RNA5-8N2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4741, 4744, 4747
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3F7
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P07196, P07197, P12036
• Gene Symbols: NEFH, NEFL, NEFM
• Immunogen: Synthetic peptide corresponding to the conserved region of human neurofilament heavy polypeptide (NEFH), medium polypeptide (NEFM) and light polypeptide (NF68, NEFL)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1