Invitrogen™ NF2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596130

Catalog No. PIPA596130

Description

Positive Samples: HeLa, 293T, HepG2; Cellular Location: Cell projection, Cytoplasm, Cytoplasmic granule, Cytoplasmic side, Nucleus, Nucleus, Peripheral membrane protein, cytoskeleton, filopodium membrane, perinuclear region, ruffle membrane Immunogen sequence: PKTFTVRIVT MDAEMEFNCE MKWKGKDLFD LVCRTLGLRE TWFFGLQYTI KDTVAWLKMD KKVLDHDVSK EEPVTFHFLA KFYPENAEEE LVQEITQHLF FLQVKKQILD EKIYCPPEAS VLLASYAVQA KYGDYDPSVH KRGFLAQEEL LPKRVINLYQ MTPEMWEERI TAWYAEHRGR ARDEAEMEYL KIAQDLEMYG VNYFAIRNKK GTELLLGVDA LGLHIYDPEN RLTPKISFPW NEIRNISYSD KEFTIKPLDK KIDVFKFNSS KLRVNKLILQ LCIGNHDLFM RRRKADSLEV QQMKAQAREE KARKQMERQR LAREKQMREE AERTRDELER RLLQMKEEAT MANEALMRSE ETADLLAEKA QITEEEAKLL AQKAAEAEQE MQRIKATAIR TEEEKRLMEQ KVLEAEVLAL KMAEESERRA KEADQLKQDL QEAREAERRA KQKLLEIATK PTYPPMNPIP APLPPDIPSF NLIGDSLSFD FKDTDMKRLS MEIEKEKVEY MEKSKHLQEQ LNELKTEIEA LKLKERETAL DILHNENSDR GGSSKHNTIK KLTLQSAKSR VAFFEEL.

NF2 encodes a protein, Merlin, that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Merlin has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Specifications

• Antigen: NF2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Nf2
• Gene Alias: ACN; BANF; Merlin; MGC123124; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromatosis 2; neurofibromin 2; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); neurofibromin 2b (merlin); neurofibromin-2; Nf2; Nf-2; NF2a; nf2b; OTTHUMP00000199607; SCH; Schwannomerlin; schwannomin
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18016, 25744, 4771
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunoprecipitation, Western Blot
• Concentration: 0.68 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P35240, P46662, Q63648
• Gene Symbols: Nf2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-595 of human NF2 (NP_0002591).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov