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Invitrogen™ NF2 Polyclonal Antibody
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Catalog No. PIPA596130
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100 μL
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PIPA596130 100 μL
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Catalog No. PIPA596130 Supplier Invitrogen™ Supplier No. PA596130
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Description

Rabbit Polyclonal Antibody

Positive Samples: HeLa, 293T, HepG2; Cellular Location: Cell projection, Cytoplasm, Cytoplasmic granule, Cytoplasmic side, Nucleus, Nucleus, Peripheral membrane protein, cytoskeleton, filopodium membrane, perinuclear region, ruffle membrane Immunogen sequence: PKTFTVRIVT MDAEMEFNCE MKWKGKDLFD LVCRTLGLRE TWFFGLQYTI KDTVAWLKMD KKVLDHDVSK EEPVTFHFLA KFYPENAEEE LVQEITQHLF FLQVKKQILD EKIYCPPEAS VLLASYAVQA KYGDYDPSVH KRGFLAQEEL LPKRVINLYQ MTPEMWEERI TAWYAEHRGR ARDEAEMEYL KIAQDLEMYG VNYFAIRNKK GTELLLGVDA LGLHIYDPEN RLTPKISFPW NEIRNISYSD KEFTIKPLDK KIDVFKFNSS KLRVNKLILQ LCIGNHDLFM RRRKADSLEV QQMKAQAREE KARKQMERQR LAREKQMREE AERTRDELER RLLQMKEEAT MANEALMRSE ETADLLAEKA QITEEEAKLL AQKAAEAEQE MQRIKATAIR TEEEKRLMEQ KVLEAEVLAL KMAEESERRA KEADQLKQDL QEAREAERRA KQKLLEIATK PTYPPMNPIP APLPPDIPSF NLIGDSLSFD FKDTDMKRLS MEIEKEKVEY MEKSKHLQEQ LNELKTEIEA LKLKERETAL DILHNENSDR GGSSKHNTIK KLTLQSAKSR VAFFEEL.

NF2 encodes a protein, Merlin, that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Merlin has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NF2
Applications ELISA, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.68 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Nf2
Gene Accession No. P35240, P46662, Q63648
Gene Alias ACN; BANF; Merlin; MGC123124; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromatosis 2; neurofibromin 2; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); neurofibromin 2b (merlin); neurofibromin-2; Nf2; Nf-2; NF2a; nf2b; OTTHUMP00000199607; SCH; Schwannomerlin; schwannomin
Gene Symbols Nf2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 19-595 of human NF2 (NP_0002591).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18016, 25744, 4771
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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