Invitrogen™ NFATC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590432

Catalog No. PIPA590432

Description

Immunogen sequence: VFGRGETLGP APRAGGTMKS AEEEHYGYAS SNVSPALPLP TAHSTLPAPC HNLQTSTPGI IPPADHPSGY GAALDGGPAG YFLSSGHTRP DGAPALESPR IEITSCLGLY HNNNQFFHDV EVEDVLPSSK RSPSTATLSL PSLEAYRDPS CLSPASSLSS RSCNSEASSY ESNYSYPYAS PQTSPWQSPC VSPKTTDPEE GFPRGLGACT LLGSPRHSPS TSPRASVTEE SWLGARSSRP ASPCNKRKYS LNGRQPPYSP HHSPTPSPHG SPRVSVTDDS W Positive Samples: Jurkat, U-87MG, K-562, Mouse spleen; Cellular Location: Cytoplasm, Nucleus.

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Specifications

• Antigen: NFATC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NFATC1
• Gene Alias: 2210017P03Rik; AI449492; AV076380; MGC138448; NFAT tra; NFAT trans; NFAT transcription complex cytosolic component; NFAT2; NFATc; NF-ATC; NFATC1; NF-ATc1; NF-ATc1.2; Nfatcb; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; nuclear factor of activated T-cells 1; nuclear factor of activated T-cells 'c'; nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; transcription factor NF-ATc
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100361818, 18018, 4772
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.63 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O88942, O95644
• Gene Symbols: NFATC1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of NFAT2 (NP_765978.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG