Invitrogen™ NFATC2IP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599664

Catalog No. PIPA599664

Description

Antibody detects endogenous levels of total NFATc2IP.

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.

Specifications

• Antigen: NFATC2IP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NFATC2IP
• Gene Alias: 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; ESC2; NFATC2-interacting protein; NFATC2IP; NIP45; nuclear factor of activated T-cells 2 interacting protein; nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein; RAD60
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84901
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8NCF5
• Gene Symbols: NFATC2IP
• Immunogen: A synthesized peptide derived from human NFATC2IP(Accession Q8NCF5), corresponding to amino acid residues A155-P205.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov