Invitrogen™ NFIA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596238

Catalog No. PIPA596238

Description

Immunogen sequence: AYFVHAADSS QSESPSQPSD ADIKDQPENG HLGFQDSFVT SGVFSVTELV RVSQTPIAAG TGPNFSLSDL ESSSYYSMSP GAMRRSLPST SSTSSTKRLK SVEDEMDSPG EEPFYTGQGR SPGSGSQSSG WHEVEPGMPS PTTLKKSEKS G; Positive Samples: Mouse brain; Cellular Location: Nucleus.

NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.

Specifications

• Antigen: NFIA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NFIA
• Gene Alias: 1110047K16Rik; 9430022M17Rik; CCAAT-box-binding transcription factor; CTF; KIAA1439; NF1A; NF1-A; Nf1l21; NF-I/A; Nfia; NFI-A; NFI-L; Nuclear factor 1 A-type; nuclear factor 1/A; nuclear factor I A; nuclear factor I/A; TGGCA-binding protein; Unknown (protein for MGC:128467)
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18027, 25492, 4774
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.52 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P09414, Q02780, Q12857
• Gene Symbols: NFIA
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-330 of human NFIA (NP_0055861).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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