NFKBIA Mouse anti-Human, Clone:4D4F2, Abnova™

Mouse monoclonal antibody raised against recombinant human NFKBIA.

Supplier:  Abnova Corporation MAB16711

Catalog No. 89-333-161

Description

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]

Specifications

• Antigen: NFKBIA
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Immunohistochemistry
  Immunocytochemistry (1:200-1:1000)
  Flow Cytometry (1:200-1:400)
  The optimal working dilution should be determined by the end user.
• Gene: NFKBIA
• Host Species: Mouse
• Quantity: 100 μg
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
• Clone: 4D4F2
• Description: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
• Formulation: In PBS (0.05% sodium azide)
• Gene Alias: IKBA, MAD-3, NFKBI
• Immunogen: Recombinant protein corresponding to amino acid 150-291 of human NFKBIA from E. coli.
• Gene ID (Entrez): 4792
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid