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Invitrogen™ NFS1 Polyclonal Antibody
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Catalog No. PIPA5117064
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100 μL
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PIPA5117064 100 μL
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Catalog No. PIPA5117064 Supplier Invitrogen™ Supplier No. PA5117064
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Description

Rabbit Polyclonal Antibody

Positive Samples: SH-SY5Y, HepG2, BxPC-3, Mouse brain, Mouse liver, Mouse heart, Rat brain, Rat liver, Rat heart Immunogen sequence: GMRSGTVPTP LVVGLGAACE VAQQEMEYDH KRISKLSERL IQNIMKSLPD VVMNGDPKHH YPGCINLSFA YVEGESLLMA LKDVALSSGS ACTSASLEPS YVLRAIGTDE DLAHSSIRFG IGRFTTEEEV DYTVEKCIQH VKRLREMSPL WEMVQDGIDL KSIKWTQH.

NFS1 (nitrogen fixation 1), also known as NIFS or IscS (cysteine desulfurase), is a member of the class V pyridoxal-phosphate-dependent aminotransferase family. It localizes to the cytoplasm or mitochondrion depending on which form is generated based on cytosolic pH. Highest expression levels of NFS1 are found in heart and skeletal muscle. Lower levels of expression are also found in liver, brain and pancreas. NFS1 is responsible for catalyzing the removal of sulfur from cysteine to form alanine, thereby supplying the inorganic sulfur for iron-sulfur (Fe-S) clusters. Fe-S clusters function as essential cofactors in a wide variety of events, including facilitation of electron transfer processes in oxidative phosphorylation, catalysis of enzymatic reactions in aconitase and dehydratases and maintenance of structural integrity in the DNA repair enzyme endonuclease III.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NFS1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.07 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene NFS1
Gene Accession No. Q99P39, Q9Y697, Q9Z1J3
Gene Alias AA987187; cysteine desulfurase, mitochondrial; Cysteine desulfurase, mitochondrial-like protein; HUSSY-08; IscS; LOW QUALITY PROTEIN: cysteine desulfurase, mitochondrial; m-Nfs1; m-Nfsl; Nfs1; NFS1 cysteine desulfurase; NFS1 nitrogen fixation 1 homolog; NFS1 nitrogen fixation 1 homolog (S. cerevisiae); NFS1, cysteine desulfurase; Nifs; nifS-like (sic); nitrogen fixation 1 (S. cerevisiae, homolog); nitrogen fixation gene 1; nitrogen fixation gene 1 (S. cerevisiae); nitrogen fixation gene, yeast homolog 1; nitrogen-fixing bacteria S-like protein
Gene Symbols NFS1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 290-457 of human NFS1 (NP_0669233).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18041, 84594, 9054
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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